What ingredients are inside Silencil?

The Silencil formula has been split between a proprietary blend (without a disclosed concentration per serving) and supporting vitamins and minerals. The 28 ingredients go as follows:

Rhodiola

Belonging to the Crassulaceae family, Rhodiola is a Chinese medicinal herb that has garnered a lot of attention for its “anti-aging activity.” A comprehensive review of this herb revealed a thing or two on its effect on the nervous system that might be of significance. For instance, it was noted that its main bioactive constituent, salidroside, “reduced neurodegeneration in tau-transgenic Drosophila and inhibited neuronal loss.”

Given the prevalent effect of oxidative stress on Alzheimer’s disease, this respective constituent is also trusted to protect neurons from such a stressor. To add to that, salidroside can eliminate inflammation, which in turn is trusted to inhibit the development of depression and related symptoms.

In the end, the authors summarized that “Rhodiola extracts and compounds display numerous bioactivities including anti-oxidative, anti-aging, anti-cancer and neuroprotective activities [however] studies were primarily conducted in vitro. Therefore, the effects of these compounds require verification in vivo. ”

Lutein 5%

Lutein is a carotenoid that has been long considered for improved vision. Many people do not know that it is as effective when it comes to enhancing brain function. According to one review, lutein can be viewed as one carrying “neuroprotective [properties] through its role as an antioxidant.” In other words, it might prevent free radical attacks on the brain, which in turn might positively influence several of our brain functions.

Another resource appears to have summarized the combined effects of lutein and zeaxanthin based on different studies. That is, the duo is believed to exhibit blood flow to specific brain regions, increase neural activation, and improve complex attention, cognitive flexibility, memory, and reasoning.

Ashwagandha

Ashwagandha (also known as Withania somnifera) is a plant belonging to the Solanaceae family. Existing studies have since discovered that it carries adaptogenic/anti-stress activities. Interestingly, it is trusted to ease neurodegenerative diseases such as Parkinson’s, Huntington’s, and Alzheimer’s, all while inducing a “GABA mimetic effect” that helps to form dendrites (i.e., extensions on nerve cells that allow for effective communication). Given its widespread acceptance, it was noted that “large scale studies are needed to prove its clinical efficacy in stress-related disorders, neuronal disorders and cancers “

Gamma-Aminobutyric Acid

Gamma-aminobutyric acid (GABA) is a type of inhibitory neurotransmitter that prevents certain brain signals to achieve a sense of calmness. One study on rats that looked at the combined effects of GABA and glutamic acid concluded that targeting such factors might help find an effective therapy for tinnitus.

Another experiment that led to the conclusion that the brain did, in fact, play a major role was able to find that “neurons [in the auditory cortex] have lost sensory input from the ear [and] become more excitable and fire spontaneously.” The approach taken by the team involved retraining patients so that their brain cells receive new input, and consequently, the firing is said to have ceased.

Bearing the aforementioned in mind, one interesting result that came from this study is a correlation between tinnitus and GABA. In particular, “tinnitus correlates with lower levels of the inhibitory neurotransmitter GABA, but not with changes in the excitatory neurotransmitters.” Hence, increasing GABA can possibly eliminate tinnitus once and for all.

Chamomile

Chamomile is an herb native to the Asteraceae family. To date, it has been consumed to induce calmness, restfulness and, to some extent, induce sleep. As per an overview provided on ScienceDirect, this herb carries sedative effects because of its ability to bind to GABA receptors. In doing so, it might increase the effect of GABA, which is crucial for calming the otherwise excited neurons in the brain.

Oat Straw

Oat Straw is extracted from a plant called Avena sativa plant, a species of cereal grass. At the time of writing, it has been appreciated for its ability to “reduce inflammation and improve brain function and mood,” writes HealthLine. Existing studies could link its source of antioxidants (i.e., avenanthramides) to improved heart health and blood flow to both the heart and brain.

This same property may lend a helping hand in reducing inflammation and its related implications. Its ability to improve brain function has been specifically tested on the elderly population, where 800 to 1600mg of oat straw per day was found to have “improved memory, attention, and concentration.”

Mucuna Pruriens

Mucuna pruriens has since been recognized as an “established herbal drug” when it comes to treating male infertility and nervous disorders. People who follow ancient Indian all-natural medicine, Ayurveda, would have seen this ingredient encouraged for Parkinson’s disease. Regarding its potential, a review explained that it “has been shown to have antiparkinson and neuroprotective effects, which may be related to its antioxidant activity.”

Valerian, Lemon Balm & Passionflower

In another post called “The 6 Best Bedtime Teas that Help Your Sleep,” three of them were listed as being valerian root, passionflower, and lemon balm. Historically speaking, valerian root has been considered as a possible treatment for insomnia. In fact, HealthLine reported that it was used during World War II to relieve stress and anxiety. What’s interesting about this herb is that it too binds to the GABA receptor, which might be the reason why it has such a calming effect.

Up next, we have lemon balm, an herb that is rooted in the mint family. Since the Middle Ages, it has allegedly been linked to reduced stress and improved sleep. Finally comes passionflower, or biologically known as the Passiflora plant. As this is being written, some studies concluded that it could significantly better sleep, possibly treating severe insomnia stages as well.

Skullcap

Like lemon balm, the skullcap is a flowering plant found in the mint family. Traditionally speaking, this ingredient has been used by Native Americans to treat “menstrual disorders, nervousness, digestive and kidney problems,” writes NCBI adding that it has a dominating effect on anxiety, stress, and insomnia. Its calming effects, once again, has been linked to its ability to trigger GABA in the brain.

Hawthorn

Hawthorn is a plant whose leaves, berries, and flowers are used for medicinal purposes. One study investigating its neuroprotective effect on rats with cerebral artery occlusion reported significant improvements in neurological behavior compared to the control group. In the end, the researchers suggested that such results might stem from its prophylactic activity, adding that its antioxidant properties might have played a role in “restor[ing] glutathione levels, circumvent[ing] the increase in lipid peroxidation and nitric oxide levels, thereby reducing peroxynitrite formation and free radical-induced brain damage.”

Bacopa Monnieri

Also known as brahmi or water hyssop, bacopa monnieri is an herb that has long been incorporated in Ayurvedic medicine. One possible reason this herb is sought for has to do with its rich source of antioxidants, which might reduce inflammation and ease ADHD symptoms and anxiety. One study that administered 300mg and 600mg of bacopa extract to a group of elderlies for 12 weeks found significant evidence for “improved attention, cognitive processing, and working memory.”

Magnolia

Magnolia is a tree whose leaves and bark are combined to create extracts. Like some of the ingredients found in Silencil, this one also possesses protective properties. For now, it has been proven to possibly protect the entire body from oxidative stress and inflammation, which in this supplement’s case implies possible protection against neurodegenerative diseases. Having said that, other areas of improvement might include blood sugar levels, heart, mental and emotional health.

L-Theanine

L-theanine is an amino acid commonly found in tea leaves. It has since been linked to increased relaxation and better sleep quality because of its ability to elevate different types of inhibitory neurotransmitters, including the likes of GABA, and serotonin, and to some extent, dopamine. The latter is deemed possible because of its ability to “cross the blood-brain barrier.

Hops

Hops are flowers from the plant, Humulus lupulus, which belongs to the Cannabaceae family. Like many others, this may ease restlessness, anxiousness, and other stress/anxiety combination of symptoms. A study that examined hop’s sedative effects on activity/rest rhythm found that a concentration as low as 2mg can go a long way. In this case, it decreased nocturnal activity in the circadian activity rhythm. One can make here that being able to sleep through tinnitus might alleviate feelings of irritation.

Griffonia Simplicifolia

Found dominantly in western Africa, Griffonia simplicifolia is a plant that has been appreciated for its active compound called 5-HTP, which is short for 5-hydroxytryptophan. As per one resource, its usefulness has been witnessed when it comes to treating insomnia. In fact, the exact mechanism supposedly involves increased serotonin levels (i.e., a neurotransmitter that enhances communication among brain cells).

St. John’s Wort

St. John’s Wort is an herb that has been historically used to treat an array of mental health concerns. Individuals might bump into over-the-counter drugs with this respective ingredient as a way to treat “mild and moderate depression, and sometimes seasonal affective disorder, mild anxiety and sleep problems”

As for the supporting vitamins and minerals, they include:

Vitamin B1 (6mg): Might stabilize the nervous system, which might lessen tinnitus symptoms
Vitamin B2 (6mg): Brain and heart-related disorders are deemed results of a vitamin B2 deficiency
Niacin (14mg): Might elicit muscle relaxation and blood flow to blood vessels in the ears
Vitamin B6 (4mg): Could help treat tinnitus, especially among the older population
Biotin (150mcg): Supports the brain when it comes to the delivery and metabolism of glucose
Pantothenic Acid (8mg): Trusted to support brain cells by producing cholesterol, amino acids, and fatty acids, among others
Calcium (13mg): Is trusted to regulate many of the brain’s neurons and neurotransmitters’ functions
Magnesium (12.5mg): Linked to brain development, memory, learning, and healthy nerve cells
Zinc (12.5mg): Plays a role in the cochlear and in the synapses of the auditory system
Potassium (12.5mg): Is said to induce circulation, which as a result might relieve tinnitus